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FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions

FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions

The U.S. Food and Drug Administration today is requiring safety labeling changes for a class of antibiotics called fluoroquinolones to strengthen the warnings about the risks of mental health side effects and serious blood sugar disturbances, and make these warnings more consistent across the labeling for all fluoroquinolones taken by mouth or given by injection. […]

EULAR recommendations for the management of antiphospholipid syndrome in adults

EULAR recommendations for the management of antiphospholipid syndrome in adults

Abstract The objective was to develop evidence-based recommendations for the management of antiphospholipid syndrome (APS) in adults. Based on evidence from a systematic literature review and expert opinion, overarching principles and recommendations were formulated and voted. High-risk antiphospholipid antibody (aPL) profile is associated with greater risk for thrombotic and obstetric APS. Risk modification includes screening […]

Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults

Management of thrombotic and obstetric antiphospholipid syndrome: a systematic literature review informing the EULAR recommendations for the management of antiphospholipid syndrome in adults

ABSTRACT Objective To perform a systematic literature review (SLR) informing the European Lmmendations for the management of antiphospholipid syndrome (APS) in adults. Methods A SLR through January 2018 was performed. Research questions were constructed using the Patient, Intervention, Comparator, Outcome (PICO) format. We included data from articles that reported on each relevant intervention. Summary effect […]

Implications of Nine Risk Prediction Models for Selecting Ever-Smokers for Computed Tomography Lung Cancer Screening

Implications of Nine Risk Prediction Models for Selecting Ever-Smokers for Computed Tomography Lung Cancer Screening

Abstract Background: Lung cancer screening guidelines recommend using individualized risk models to refer ever-smokers for screening. However, different models select different screening populations. The performance of each model in selecting ever-smokers for screening is unknown. Objective: To compare the U.S. screening populations selected by 9 lung cancer risk models (the Bach model; the Spitz model; […]

Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014

Oral Human Papillomavirus Infection: Differences in Prevalence Between Sexes and Concordance With Genital Human Papillomavirus Infection, NHANES 2011 to 2014

  ABSTRACT Background: The burden of human papillomavirus (HPV)-positive oropharyngeal squamous cell carcinoma (OPSCC) is disproportionately high among men, yet empirical evidence regarding the difference in prevalence of oral HPV infection between men and women is limited. Concordance of oral and genital HPV infection among men is unknown. Objective: To determine the prevalence of oral […]

Προσυμπτωματικός καρδιολογικός έλεγχος διαβητικών ασθενών

Προσυμπτωματικός καρδιολογικός έλεγχος διαβητικών ασθενών

Άρθρο ανασκόπησης για το θέμα του προσυμπτωματικού καρδιολογικού ελέγχου διαβητικών ασθενών. Το άρθρο είναι ελεύθερα διαθέσιμο στο site του περιοδικού Journal of Diabetes Research: Cardiovascular Screening for the Asymptomatic Patient with Diabetes: More Cons Than Pros 

Herpes zoster vaccine (Shingrix, GlaxoSmithKline) to prevent shingles

Herpes zoster vaccine (Shingrix, GlaxoSmithKline) to prevent shingles

Drug regulators in Europe and Japan have approved a recombinant, adjuvanted herpes zoster vaccine (Shingrix, GlaxoSmithKline) to prevent shingles (in Europe and Japan) and postherpetic neuralgia (in Europe only) in adults aged 50 years or older, the company has announced. Shingles is caused when the same varicella zoster virus that causes chickenpox becomes reactivated. In most […]

Our Other Prescription Drug Problem

Our Other Prescription Drug Problem

The epidemic of opioid addiction and overdose has appropriately garnered national attention and led to concerted efforts to reduce overprescribing of opioids, a major cause of today’s drug crisis. By contrast, there has been little effort to address inappropriate prescribing of benzodiazepines–controlled substances such as alprazolam, clonazepam, diazepam, and lorazepam.   Read more at N […]

Μετά τη μετφορμίνη οι αντιδιαβητικές αγωγές του θεραπευτικού αλγόριθμου στον Σακχαρώδη Διαβήτη τύπου ΙΙ: Σύγχρονα δεδομένα και νέες θεραπευτικές στρατηγικές (Α. Μελιδώνης)

Μετά τη μετφορμίνη οι αντιδιαβητικές αγωγές του θεραπευτικού αλγόριθμου στον Σακχαρώδη Διαβήτη τύπου ΙΙ: Σύγχρονα δεδομένα και νέες θεραπευτικές στρατηγικές (Α. Μελιδώνης)

Δρ. Α. Μελιδώνης Παθολόγος – Διαβητολόγος, Συντονιστής Διευθυντής Α΄ Παθολογικής Κλινικής & Διαβητολογικού Κέντρου, «Τζάνειο» Νοσοκομείο   Η θεραπευτική αντιμετώπιση του ΣΔτ2 αποσκοπεί στην ουσιαστική μείωση ή και αποτροπή των επιπλοκών του διαβήτη. Ουσιαστικό ρόλο στα πλαίσια της πολυπαραγοντικής αντιμετώπισης του διαβητικού ασθενούς, διαδραματίζει η επίτευξη γλυκαιμικής ρύθμισης, όσο το δυνατόν νωρίτερα στη διαδρομή εξέλιξης […]

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

Acute Myocardial Infarction after Laboratory-Confirmed Influenza Infection

BACKGROUND Acute myocardial infarction can be triggered by acute respiratory infections. Previous studies have suggested an association between influenza and acute myocardial infarction, but those studies used nonspecific measures of influenza infection or study designs that were susceptible to bias. We evaluated the association between laboratory-confirmed influenza infection and acute myocardial infarction. METHODS We used […]

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